Our research interests
Evolutionary pressure has lead to the development of remarkably precise and rapid information processing in our central nervous system. Visual and vestibular signals, for example, can be processed with high precision within split seconds. Most of the underlying cellular mechanisms remain poorly understood.
Our group aims to understand the mechanisms of high-frequency signaling on various levels, ranging from single molecule to neuronal networks. We use cutting-edge electrophysiological, optical, genetic and computational methods, such as direct whole-cell patch-clamp recordings from presynaptic nerve terminals, capacitance measurements and two-photon calcium imaging. We are also driven by the chance that basic neuroscience research will help advance the limited therapeutic possibilities in psychiatry and neurology.
Our group is currently funded by the Heisenberg-Program of the German Research Foundation (DFG).
Delvendahl I, Vyleta NP, von Gersdorff H, Hallermann S (2016)Fast, temperature-sensitive and clathrin-independent endocytosis at central synapses.Neuron in press
Delvendahl I, Jablonski L, Baade C, Matveev V, Neher E, Hallermann S (2015)Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.Proc Natl Acad Sci U S A 112:E3075-E3084
Ritzau-Jost A*, Delvendahl I*, Rings A*, Byczkowicz N, Harada H, Shigemoto R, Hirrlinger J, Eilers J, Hallermann S (2014)Ultrafast action potentials mediate kilohertz signaling at a central synapse.Neuron 84:152-163
Hallermann S, Silver RA (2013)Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering.Trends Neurosci 36:185-94
Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012)State and location dependence of action potential metabolic cost in cortical pyramidal neurons.Nat Neurosci 15:1007-1014
Hallermann S, Fejtova A, Schmidt H, Weyhersmüller A, Silver RA, Gundelfinger ED, Eilers J (2010)Bassoon speeds vesicle reloading at a central excitatory synapse.Neuron 68:710-723