Our research interests
The ability to learn and memorize is crucial throughout our entire life. Learning and memory is mediated by trillions of chemical synapses connecting the nerve cells in our brain. One of the key mechanisms of learning and memory is synaptic plasticity – the strengthening and weakening of these synapses.
Despite intense efforts, fundamental mechanisms of the function and plasticity of chemical synapses remains unclear. Particularly, the mechanisms mediating neurotransmitter release at presynaptic nerve endings is challenging to investigate, because the underlying processes are small and fast and have complex biophysics: Tiny transmitter-filled vesicles with a diameter of 50 nm fuse with the plasma membrane within less than 100 µs upon arrival on an action potential to release the neurotransmitter.
Our group aims to understand presynaptic function and plasticity on various levels, ranging from single molecules to neuronal networks. To this end, we apply and develop new electrophysiological, optical, genetic, and computational techniques, which allow us to push the spatial and temporal resolution beyond the state of the art. This allowed us, for example, to measure synaptic transmission at a frequency of about 1 kHz at a synapse in the cerebellum. Besides our excitement to investigate sofar inaccessible processes, we are driven by the chance that basic neuroscience research helps advancing the limited therapeutic possibilities in psychiatry and neurology.
Selected recent publications
Byczkowicz N, Eshra A, Montanaro J, Trevisiol A, Hirrlinger J, Kole MH, Shigemoto R, Hallermann S (2019)HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.Elife 8. pii:e42766
Haselmann H, Mannara F, Werner C, Planagumà J, Miguez-Cabello F, Schmidl L, Grünewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klöcker N, Soto D, Doose S, Dalmau J, Hallermann S, Geis C (2018)Human autoantibodies against the AMPA receptor subunit GluA2 induce receptor reorganization and memory dysfunction.Neuron 100:91-105
Delvendahl I, Vyleta NP, von Gersdorff H, Hallermann S (2016)Fast, temperature-sensitive and clathrin-independent endocytosis at central synapses.Neuron 90:492-498
Delvendahl I, Jablonski L, Baade C, Matveev V, Neher E, Hallermann S (2015)Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.Proc Natl Acad Sci U S A 112:E3075-E3084
Ritzau-Jost A*, Delvendahl I*, Rings A*, Byczkowicz N, Harada H, Shigemoto R, Hirrlinger J, Eilers J, Hallermann S (2014)Ultrafast action potentials mediate kilohertz signaling at a central synapse.Neuron 84:152-163