DFG founded research groups » Research Group Schmidt » People » Grit Bornschein

Dr.rer.nat. Grit Bornschein (née Schaarschmidt)
University of Leipzig, Medical Faculty
Carl-Ludwig-Institute for Physiology, Dep. II
Liebigstraße 27, 04103 Leipzig, Germany
phone: (+49) 341 9715522
email: grit.bornschein@medizin.uni-leipzig.de
Room E201

Curriculum Vitae

Education & Scientific Career

2011 European Synapse Summer School, FENS-IBRO Training Centre Bordeaux, France
since 2009 Research fellow, Carl-Ludwig-Institute for Physiology, University of Leipzig, Germany
2006 – 2009 PhD thesis; Department of Neurology, University of Leipzig, Germany
2006 License to practice pharmacy (Approbation)
2004 – 2005 Diploma in pharmacy; Institute for Applied Dermatopharmacy, Martin-Luther-University Halle-Wittenberg, Germany
2000 – 2004 Studies of pharmacy; Martin-Luther-University Halle-Wittenberg, Germany


  • Wender M*, Bornschein G*, Brachtendorf S, Hallermann S, Eilers J, Schmidt H (*equally contributed)
    Cav2.2 channels sustain vesicle recruitment at a mature glutamatergic synapse.
    J Neurosci 202343(22): 4005-4018
  • Paul MM, Dannhäuser S, Morris L, Mrestani A, Hübsch M, Gehring J, Hatzopoulos GN, Pauli M, Auger GM, Bornschein G, Scholz N, Ljaschenko D, Müller M, Sauer M, Schmidt H, Kittel RJ, DiAntonio A, Vakonakis I, Heckmann M, Langenhan T
    The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.
    Brain 2022; 145(11): 3787-3802
  • Bornschein G, Brachtendorf S, Schmidt H.
    Developmental Increase of Neocortical Presynaptic Efficacy via Maturation of Vesicle Replenishment.
    Front Synaptic Neurosci 2020; 15: 11-36
  • Bornschein G, Eilers J, Schmidt H
    Neocortical high probability release sites are formed by distinct Ca2+ channel to release sensor topographies during development.
    Cell Rep 2019; 28(6): 1410-1418 e1414.
  • Bornschein G, Schmidt H
    Synaptotagmin Ca2+ sensors and their spatial coupling to presynaptic Cav channels in central cortical synapses.
    Front Mol Neurosci 2018; 11: 494-510
  • Kusch V*, Bornschein G*, Loreth D, Bank J, Jordan J, Baur D, Watanabe M, Kulik A, Heckmann M, Eilers J, Schmidt H (*equally contributed)
    Munc13-3 is required for the developmental localization of Ca2+ channels to active zones and the nanopositioning of Cav2.1 near release sensors.
    Cell Reports 2018 ; 22, 1965-1973
  • Baur D, Bornschein G, Althof D, Watanabe M, Kulik A, Eilers J, Schmidt H
    Developmental tightening of cerebellar cortical synaptic influx-release coupling.
    J Neurosci 2015; 35(5): 1858-1871.
  • Bornschein G, Arendt O, Hallermann S, Brachtendorf S, Eilers J, Schmidt H.
    Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.
    J Physiol 2013 ; 591 (Pt 13): 3355-3370.
  • Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Krügel U, Ziegler WH, Hirrlinger J.
    Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells.
    Glia 2013; 61 (7): 1067-1083
  • Schmidt H, Brachtendorf S, Arendt O, Hallermann S, Ishiyama S, Bornschein G, Gall D, Schiffmann SN, Heckmann M, Eilers J
    Nanodomain coupling at a cortical excitatory synapse.
    Curr Biol 2013; 23(3): 244-249
  • Wegner F, Kraft R, Busse K, Schaarschmidt G, Härtig W, Schwarz SC, Schwarz J.
    Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro.
    J Neurochem 2009; 111 (1): 204-216.
  • Schaarschmidt G, Wegner F, Schwarz SC, Schmidt H, Schwarz J.
    Characterization of voltage-gated potassium channels in human neural progenitor cells.
    PLoS ONE 2009; 4 (7) : e6168.
  • Schaarschmidt G*, Schewtschik S*, Kraft R, Wegner F, Eilers J, Schwarz J, Schmidt H.
    (*equally contributed)
    A new culturing strategy optimizes functional neuronal development of human neural precursor cells.
    J Neurochem 2009; 109 (1): 238-47.
  • Wegner F, Kraft R, Busse K, Härtig W, Schaarschmidt G, Schwarz J, Eilers J, Hevers W.
    Functional analysis of GABAA receptors in human midbrain-derived neural precursor cells.
    J Neurochem 2008; 107 (4): 1056-1069.
  • Rzepka K, Schaarschmidt G, Nagler M, Wohlrab J.
    Epidermal stem cells.
    J Dtsch Dermatol Ges 2005; 3 (12): 962-73.