Recent publications

Abteilung I Hallermann » Mitarbeiter » Christian Simon


Christian Simon, PhD

Carl-Ludwig-Institute for Physiology Leipzig University,
Liebigstr. 27, 04103 Leipzig, Germany
Room E105
phone: +49 (0) 341 97 15325

Curriculum Vitae


2008 - 2012 PhD in Natural Science, (Lab: Prof. Michael Sendtner) Institute for Clinical Neurobiology, Julius-Maximilians-University, Würzburg, Germany.
2004 - 2007 Diploma in Biology, Thesis (Lab: Prof. Michael Sendtner), Institute for Clinical Neurobiology, Julius-Maximilians-University, Würzburg, Germany.
2002 - 2004 Prediploma in Biology, Justus-Liebig-University, Giessen, Germany

Scientific career

Since 2017 Research Associate (Lab: Prof. Stefan Hallermann) at Carl-Ludwig-Institute of Physiology, Leipzig University, Leipzig, Germany
2016 - 2017 Research Associate (Lab: Prof. George Mentis) at The Motor Neuron Center for Biology Disease, Columbia University, New York, USA
2012 - 2016 Postdoctoral Fellow (Lab: Prof. George Mentis) at The Motor Neuron Center for Biology Disease, Columbia University, New York, USA
2007 Visiting fellow (Lab: Prof. Gregory Macleod), Health Science Center, University of Texas, San Antonio, USA
2005 Visiting fellow (Lab: Prof. Konrad Zinsmaier), Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, USA
2004 Student assistant (Lab: Prof. Betram Gerber), Institute of Neurobiology & Genetics, Julius-Maximilians-University, Würzburg, Germany

Research Awards

2013 Roche Translational & Clinical Research Center - Young Investigator Award “Mechanisms of synaptic, cellular and circuit dysfunction involved in SMA“


  • Simon CM, Dai Y, Van Alstyne M, Koutsioumpa C, Pagiazitis JG, Chalif JI, Wang X, Rabinowitz JE, Pellizzoni L, Henderson CE, Mentis GZ (2017)
    Converging mechanisms of p53 activation drive motor neuron degeneration in spinal muscular atrophy.
    Cell Reports 21, 3767–3780
  • Fletcher EV, Simon, CM, Pagiazitis, JG, Chalif, JI, Vukojicic, A, Drobac, E, Wang, X, and Mentis, GZ (2017)
    Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
    Nature neuroscience 20, 905-916
  • Simon CM, Janas A.M, Lotti F, Tabia JC, Pellizzoni L, Mentis GZ (2016)
    A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency
    Cell Reports 16, 1416–1430
  • Jesse CM, Bushuven E, Tripathi P, Chandrasekar A, Simon CM, Drepper C, Yamoah A, Dreser A, Katona I, Johann S, Beyer C, Wagner S, Grond M, Nikolin S, Anink J, Troost D, Sendtner M, Goswami A, Weis J (2016)
    ALS-associated endoplasmic reticulum proteins in denervated skeletal muscle: Implications for motor neuron disease pathology.
    Brain Pathology doi: 10.1111/bpa.12453
  • Mendelsohn AI, Simon CM, Abbott LF, Mentis GZ, Jessell T (2015
    Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.
    Neuron Jul 1;87(1):111-23
  • Simon CM, Gunnersen JM, Rauskolb S, Holtmann B, Drepper C, Braga M, Wiese S, Jablonka S, Puehringer D, Dombert B, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka K, Sendtner M (2015)
    Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
    Acta Neuropathol. 10.1007/s00401-015-1446-8
  • de Nooij JC, Simon CM, Simon A, Doobar S, Steel KP, Banks RW, Mentis GZ, Bewick GS, Jessell T (2015)
    The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.
    J Neurosci. 35(7):3073-84
  • Dombert B, Sivadasan R, Simon CM, Jablonka S, Sendtner M (2014)
    Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons.
    PLoS One, 10; 9(10):e110846
  • Simon CM, Jablonka, S, Ruiz, R, Tabares, L, Sendtner, M (2010)
    Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of spinal muscular atrophy.
    Hum. Mol. Genet., 19 973-986
  • Fischer, M, Pereira, PM, Holtmann, B, Simon, CM, Hanauer, A, Heisenberg, M, Sendtner, M (2009)
    P90 ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
    Mol. Cell Neurosci., 42 134-141