Department I Hallermann » People » Stefan Hallermann


Prof. Dr. med. Dipl. phys. Stefan Hallermann

Carl-Ludwig-Institute for Physiology
University Leipzig, Liebigstr. 27, 04103 Leipzig, Germany
Room D103

phone: +49 (0) 341 97 15501
fax: +49 (0) 341 97 15509

Curriculum Vitae

Scientific career

Since 2016 Full Professor and head of Department I, Carl-Ludwig-Institute of Physiology, University Leipzig, Germany
2013-2016 Heisenberg-Professor, Carl-Ludwig-Institute of Physiology, University Leipzig, Germany
2011-2013 Group leader, European Neuroscience Institute Göttingen, Germany
2008-2011 Research fellow, Carl-Ludwig-Institute of Physiology, University Leipzig, Germany
2006-2007 Research fellow, Institute for Clinical Neurobiology, Julius-Maximilians-University Würzburg, Germany
2004 Visiting fellow, John Curtin School, Division of Neuroscience, Canberra, Australia
2000-2005 Student assistant and research fellow, Institute of Physiology, Albert-Ludwigs-University Freiburg
1998-2000 Student assistant, Institute of Physiology, Technical University Munich


2005 Licence to practise medicine (Approbation)
1998-2004 Medicine, Ludwig-Maximilians-University, Munich, Germany and Albert-Ludwigs-University, Freiburg i. Br., Germany
1995-2000 Physics, Ludwig-Maximilians-University, Munich, Germany


2020 ERC consolidator grant (CoG-865634 PreSynPlast)
Since 2019 Co-speaker of the DFG Research Unit 3004 Synaptic pathology in autoimmune encephalitis (SYNABS)”
Since 2017 Mentor for the German National Academic Foundation (Vertrauensdozent der Studienstiftung des deutschen Volkes)
Since 2016 Member of the panel for state-wise medical examinations (IMPP)
2016 Research Grant, German Research Foundation (HA 6386/4-1)
2013-2016 Heisenberg-Professor, German Research Foundation (HA 6386/3-1)
2011 Research Grant, German Research Foundation (HA 6386/2-1)
2011-2013 Heisenberg-Fellowship, German Research Foundation (HA 6386/1-1)
2011 Du Bois-Reymond award, German Physiological Society
2001-2003 Fellowship, German National Academic Foundation (Studienstiftung des deutschen Volkes)


ORCID                                    ORCID

  • Straub I, Witter L, Eshra A, Hoidis M, Byczkowicz N, Maas S, Delvendahl I, Dorgans K, Savier E, Bechmann I, Krueger M, Isope P, Hallermann S (2020)
    Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity.
    Elife 9. pii:e51771
  • Byczkowicz N, Eshra A, Montanaro J, Trevisiol A, Hirrlinger J, Kole MH, Shigemoto R, Hallermann S (2019)
    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.
    Elife 8. pii:e42766
  • Eshra A, Hirrlinger P, Hallermann S (2019)
    Enriched environment shortens the duration of action potentials in cerebellar granule cells.
    Front Cell Neurosci 13:289
  • Hallermann S, Schmidt RF (2019)
    Arbeitsweise von Synapsen.
    Springer, Physiologie des Menschen, 32. Aufl., DOI: 10.1007/978-3-662-56468-4_9
  • Hallermann S, Schmidt RF (2019)
    Neurotransmitter und ihre Rezeptoren.
    Springer, Physiologie des Menschen, 32. Aufl., DOI: 10.1007/978-3-662-56468-4_10
  • Hallermann S, Schmidt RF (2019)
    Synaptische Plastizität.
    Springer, Physiologie des Menschen, 32. Aufl., DOI: 10.1007/978-3-662-56468-4_11
  • Scholz N, Ehmann N, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T, Kittel RJ. (2019)
    Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
    J Cell Biol 218:1011-1026
  • Ritzau-Jost A, Hallermann S (2018)
    Presynaptic Calcium En Passage through the Axon.
    Biophys J 115:1143-1145
  • Haselmann H, Mannara F, Werner C, Planagumà J, Miguez-Cabello F, Schmidl L, Grünewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klöcker N, Soto D, Doose S, Dalmau J, Hallermann S, Geis C (2018)
    Human autoantibodies against the AMPA receptor subunit GluA2 induce receptor reorganization and memory dysfunction.
    Neuron 100:91-105
  • Ritzau-Jost A, Jablonski L, Viotti J, Lipstein N, Eilers J, Hallermann S (2018)
    Apparent calcium dependence of vesicle recruitment.
    J Physiol 596:4693-4707 [comment by Jackman and von Gersdorff, J Physiol 596:4555–4557]
  • Byczkowicz N, Ritzau-Jost A, Delvendahl I, Hallermann S (2018)
    How to maintain active zone integrity during high-frequency transmission.
    Neurosci Res 127:61-69.
  • Schmidt N, Kollewe A, Constantin CE, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte U (2017)
    Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance.
    Neuron 96:827-838
  • Delvendahl I, Hallermann S (2016)
    The Cerebellar Mossy Fiber Synapse as a Model for High-Frequency Transmission in the Mammalian CNS.
    Trends Neurosci 39:722-737
  • Weise D, Mann J, Rumpf JJ, Hallermann S, Classen J (2017)
    Differential Regulation of Human Paired Associative Stimulation-Induced and Theta-Burst Stimulation-Induced Plasticity by L-type and T-type Ca2+ Channels.
    Cereb Cortex 27:4010-4021
  • Delvendahl I, Vyleta NP, von Gersdorff H, Hallermann S (2016)
    Fast, temperature-sensitive and clathrin-independent endocytosis at central synapses.
    Neuron 90:492-8 [comment by Brockmann M and Rosenmund C, Neuron 90:423-4]
  • Baade C, Byczkowicz N, Hallermann S (2016)
    NMDA receptors amplify mossy fiber synaptic inputs at frequencies up to at least 750 Hz in cerebellar granule cells.
    Synapse doi: 10.1002/syn.21898
  • Hallermann S (2016)
    Looking into the black box of synaptic vesicle recruitment.
    Neuron 88:435-437
  • Delvendahl I, Jablonski L, Baade C, Matveev V, Neher E, Hallermann S (2015)
    Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.
    Proc Natl Acad Sci U S A 112:E3075-3084
  • Delvendahl I, Straub I, Hallermann S (2015)
    Dendritic patch-clamp recordings from cerebellar granule cells demonstrate electrotonic compactness.
    Front Cell Neurosci 9:93
  • Paul MM, Pauli M, Ehmann N, Hallermann S, Sauer M, Kittel RJ, Heckmann M (2015)
    Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation.
    Front Cell Neurosci 9:29
  • Hallermann S (2014)
    Vesicular release of transmitter at active zones.
    in Cull-Candy, S. (ed.) Synapses, Neurotransmitters and Receptor Channels: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at
  • Ritzau-Jost A*, Delvendahl I*, Rings A*, Byczkowicz N, Harada H, Shigemoto R, Hirrlinger J, Eilers J, Hallermann S (2014)
    Ultrafast action potentials mediate kilohertz signaling at a central synapse.
    Neuron 84:152-163
  • Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ (2014)
    Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states.
    Nat Commun 5:4650
  • Hallermann S (2014)
    Calcium channels for endocytosis.
    J Physiol 592:3343-3344
  • Delvendahl I, Weyhersmüller A, Ritzau-Jost A, Hallermann S (2013)
    Hippocampal and cerebellar mossy fibre boutons - same name, different function.
    J Physiol 591:3179-3188
  • Hallermann S, Silver RA (2013)
    Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering.
    Trends Neurosci 36:185-194
  • Schmidt S, Brachtendorf S, Arendt O, Hallermann S, Ishiyama S, Bornschein G, Gall D, Schiffmann S, Heckmann M, Eilers J (2013)
    Nanodomain coupling at an excitatory cortical synapse.
    Curr Biol 23:244-9
  • Bornschein G, Arendt O, Hallermann S, Brachtendorf S, Eilers J, Schmidt H (2013)
    Paired-pulse facilitation at recurrent purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.
    J Physiol 591:3355-70
  • Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012)
    State and location dependence of action potential metabolic cost in cortical pyramidal neurons.
    Nat Neurosci 15:1007-1014
  • Weyhersmüller A*, Hallermann S*, Wagner N, Eilers J (2011)
    Rapid active zone remodeling during synaptic plasticity.
    J Neurosci 31:6041-6052 [comment in This week in the journal]
  • Saumweber T, Weyhersmüller A, Hallermann S, Diegelmann S, Michels B, Bucher D, Funk N, Reisch D, Krohne G, Wegener S, Buchner E, Gerber B (2011)
    Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47.
    J Neurosci 31:3508-3518
  • Hallermann S, Fejtova A, Schmidt H, Weyhersmüller A, Silver RA, Gundelfinger ED, Eilers J (2010)
    Bassoon speeds vesicle reloading at a central excitatory synapse.
    Neuron 68:710-723 [comment by Joselevitch C and Zenisek D, Neuron 68:604-606]
  • Hallermann S*, Kittel RJ*, Wichmann C*, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M (2010)
    Naked dense bodies provoke depression.
    J Neurosci 30:14340-14345
  • Hallermann S, Heckmann M, Kittel RJ (2010)
    Mechanisms of short-term plasticity at neuromuscular active zones of Drosophila.
    HFSP J 4:72-84
  • Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts A, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ,. Toyka KV, Heckmann M*, Sommer C* (2010)
    Stiff person syndrome associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.
    Brain 133: 3166-3180 [comment by Vincent A, Brain 133:3166-3180]
  • Meuth SG, Herrmann AM, Simon OJ, Siffrin V, Melzer N, Bittner S, Meuth P, Langer HF, Hallermann S, Boldakowa N, Herz J, Munsch T, Landgraf P, Aktas O, Heckmann M, Lessmann V, Budde T, Kieseier BC, Zipp F, Wiendl H (2009)
    Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.
    J Neurosci 29:15397-15409
  • Fouquet W, Owald D, Wichmann C, Mertel S, Depner H, Dyba M, Hallermann S, Kittel RJ, Eimer S, Sigrist SJ. (2009)
    Maturation of active zone assembly by Drosophila Bruchpilot.
    J Cell Biol 186:129-145
  • Schmid A*, Hallermann S*, Kittel RJ, Khorramshahi O, Frölich AM, Quentin C, Rasse TM, Mertel S, Heckmann M, Sigrist SJ (2008)
    Activity-dependent site-specific changes of glutamate receptor composition in vivo.
    Nat Neurosci 11:659-666 [comment in Neurobiology Select, Cell 143:5-7]
  • Heckmann M, Hallermann S (2007)
    Fast Drug Application.
    In: Patch-Clamp Analysis Neuromethods 38:295-307
  • Kole MH*, Hallermann S*, Stuart G. (2006)
    Single Ih channels in pyramidal neuron dendrites: properties, distribution and impact on action potential output.
    J Neurosci 26:1677-1687
  • Kittel RJ, Hallermann S, Thomsen S, Wichmann C, Sigrist SJ, Heckmann M (2006)
    Active zone assembly and synaptic release.
    Biochem Soc Trans 34:939-941
  • Hallermann S, Heckmann S, Dudel J, Heckmann M (2005)
    Short openings in high resolution single channel recordings of mouse nicotinic receptors.
    J Physiol 563:645-662
  • Hallermann S, Pawlu C, Jonas P, Heckmann M (2003)
    A large pool of releasable vesicles in a cortical glutamatergic synapse.
    Proc Natl Acad Sci U S A 100:8975-8980 [comment by Kushmerick C and von Gersdorff H, Proc Natl Acad Sci U S A 100:8618-8620]
  • Dudel J, Hallermann S, Heckmann M (2000)
    Quartz glass pipette puller operating with a regulated oxy-hydrogen burner.
    Pflügers Arch 41:175-180

*equally contributing