Department I Hallermann » People » Baeza Lehnert


Curriculum Vitae

Education and training

2015- 2020 PhD in Cellular and Molecular Biology, Universidad Austral & Centro de Estudios Científicos (CECs), Chile. Thesis Project: Characterization of the energy fluxes and energy homeostasis control at rest and during neurotransmission in hippocampal neurons. Tutor: Dr. L. Felipe Barros
2005-2013 Biochemist degree, Universidad Austral & Centro de Estudios Científicos (CECs), Chile. Thesis Project: Acute modulation of lactate over the rate of glucose consumption but not over transport in olfactory bulb neurons. Tutor: Dr. L. Felipe Barros

Scientific Career

Since 2021 Postdoctoral Fellow in the laboratory of Prof. Dr. Stefan Hallermann at Carl-Ludwig-Institute of Physiology, Leipzig University, Germany.
2013 -2015 Research assistant in the laboratory of Dr. L. Felipe Barros at the Center for Scientific Studies, Valdivia, Chile.


2021 EMBO Postdoctoral Fellowship
2019 ISCBFM travel grant and CAJAL programme grant to participate in the prestigious advanced neuroscience training at the Bordeaux school of Neuroscience.
2015-2019 CONICYT - Chile, Fellowship for PhD students.


  • Baeza-Lehnert F, Flores CA, Guequén A, Barros LF.
    Monitoring Lactate Dynamics in Individual Macrophages with a Genetically Encoded Probe.
    Methods Mol Biol. 2020;2184:19-30. doi: 10.1007/978-1-0716-0802-9_2.
  • Barros LF, San Martín A, Ruminot I, Sandoval PY, Baeza-Lehnert F, Arce-Molina R, Rauseo D, Contreras-Baeza Y, Galaz A, Valdivia S.
    Fluid Brain Glycolysis: Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate.
    Neurochem Res. 2020 Jun;45(6):1328-1334. doi: 10.1007/s11064-020-03005-2. Epub 2020 Mar 6.
  • Barros LF, Ruminot I, San Martín A, Lerchundi R, Fernández-Moncada I, Baeza-Lehnert F.
    Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur.
    Neurochem Res. 2020 Jan 24. doi: 10.1007/s11064-020-02964-w. Online ahead of print.
  • Contreras-Baeza Y, Sandoval PY, Alarcón R, Galaz A, Cortés-Molina F, Alegría K, Baeza-Lehnert F, Arce-Molina R, Guequén A, Flores CA, San Martín A, Barros LF.
    Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments.
    J Biol Chem. 2019 Dec 27;294(52):20135-20147. doi: 10.1074/jbc.RA119.009093. Epub 2019 Nov 12.
  • Barros LF, Baeza-Lehnert F.
    Perfect energy stability in neurons. Aging (Albany NY).
    2019 Sep 9;11(17):6622-6623. doi: 10.18632/aging.102257. Epub 2019 Sep 9.PMID: 31503004
  • Baeza-Lehnert F, Saab AS, Gutiérrez R, Larenas V, Díaz E, Horn M, Vargas M, Hösli L, Stobart J, Hirrlinger J, Weber B, Barros LF.
    Non-Canonical Control of Neuronal Energy Status by the Na(+) Pump.
    Cell Metab. 2019 Mar 5;29(3):668-680.e4. doi: 10.1016/j.cmet.2018.11.005. Epub 2018 Dec 6. PubMed PMID: 30527744.
  • Barros LF, San Martín A, Ruminot I, Sandoval PY, Fernández-Moncada I, Baeza-Lehnert F, Arce-Molina R, Contreras-Baeza Y, Cortés-Molina F, Galaz A,Alegría K.
    Near-critical GLUT1 and Neurodegeneration.
    J Neurosci Res. 2017 Nov;95(11):2267-2274. doi: 10.1002/jnr.23998. Epub 2017 Feb 2. Review. PubMed PMID: 28150866.
  • Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B.
    In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.
    Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19. PubMed PMID: 26698914.
  • Lerchundi R, Fernández-Moncada I, Contreras-Baeza Y, Sotelo-Hitschfeld T, Mächler P, Wyss MT, Stobart J, Baeza-Lehnert F, Alegría K, Weber B, Barros LF.
    NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting.
    Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11090-5. doi: 10.1073/pnas.1508259112. Epub 2015 Aug 18. PubMed PMID: 26286989; PubMed Central PMCID: PMC4568276.
  • San Martín A, Sotelo-Hitschfeld T, Lerchundi R, Fernández-Moncada I, Ceballo S, Valdebenito R, Baeza-Lehnert F, Alegría K, Contreras-Baeza Y, Garrido-Gerter P, Romero-Gómez I, Barros LF.
    Single-cell imaging tools for brain energy metabolism: a review.
    Neurophotonics. 2014 Jul;1(1):011004. doi: 10.1117/1.NPh.1.1.011004. Epub 2014 May 29. PubMed PMID: 26157964; PubMed Central PMCID: PMC4478754.
  • San Martín A, Ceballo S, Baeza-Lehnert F, Lerchundi R, Valdebenito R, Contreras-Baeza Y, Alegría K, Barros LF.
    Imaging mitochondrial flux in single cells with a FRET sensor for pyruvate.
    PLoS One. 2014 Jan 21;9(1):e85780. doi: 10.1371/journal.pone.0085780. eCollection 2014. PubMed PMID: 24465702; PubMed Central PMCID: PMC3897509.
  • Barros LF, San Martín A, Sotelo-Hitschfeld T, Lerchundi R, Fernández-Moncada I, Ruminot I, Gutiérrez R, Valdebenito R, Ceballo S, Alegría K, Baeza-Lehnert F, Espinoza D.
    Small is fast: astrocytic glucose and lactate metabolism at cellular resolution.
    Front Cell Neurosci. 2013 Mar 22;7:27. doi: 10.3389/fncel.2013.00027. eCollection 2013. PubMed PMID: 23526722; PubMed Central PMCID: PMC3605549.