PD Dr. rer. nat. habil. Dipl.-Biophysiker Robert Kraft

Carl-Ludwig-Institute for Physiology
Universität Leipzig, Liebigstr. 27, 04103 Leipzig, Germany
Room E206

phone: +49 (0) 341 97 15528
email: robert.kraft@medizin.uni-leipzig.de

Curriculum Vitae

Publications

• Röthe J, Kraft R, Ricken A, Kaczmarek I, Matz-Soja M, Winter K, Dietzsch AN, Buchold J, Ludwig MG, Liebscher I, Schöneberg T, Thor D (2024)

  The mouse adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development. 

  Commun Biol 7:104.
• Kaczmarek I, Wower I, Ettig K, Kuhn C, Kraft R, Landgraf K, Körner A, Schöneberg T, Horn S, Thor D (2023)

  Identifying GPCRs involved in adipose tissue function using the innovative RNA-seq database FATTLAS.

  iScience 26:107841.
• Peters, A, Rabe P, Liebing AD, Krumbholz P, Nordström, A, Jäger, E, Kraft R, Stäubert C (2022) 
  Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite sensing receptors with opposing functions in innate immune cells.
  Pharmacol Res 176:106047.
• Rabe P, Liebing AD, Krumbholz P, Kraft R, Stäubert C (2022) 
  Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine.
  Cancer Lett 526:91-102.
• Kraft R (2021)

  Patch Clamp Method.

  In: An Introduction to Molecular Biotechnology: Fundamentals, Methods and Applications, 3^rd Edition. Wink (Ed.), Wiley-VCH, Weinheim, 181-185.
• Peters A, Rabe P, Krumbholz P, Kalwa H, Kraft R, Schöneberg T, Stäubert C (2020)
  Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
  Cell Commun Signal 18:31.
• Röthe J, Kraft R, Schöneberg T, Thor D (2020)
  Exploring G protein-coupled receptor signaling in primary pancreatic islets.
  Biol Proced Online 22:4.
• Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft* R, Nieswandt* B (2019) 
  Loss of Orai2-mediated capacitative Ca²⁺ entry is neuro-protective in acute ischemic stroke.
  Stroke 50:3238-3245.
• Röthe* J, Thor* D, Winkler J, Knierim AB, Binder C, Huth S, Kraft R, Rothemund S, Schöneberg T, Prömel S (2019)  
  Involvement of the adhesion GPCRs latrophilins in the regulation of insulin release. 
  Cell Rep 26:1573-1584.
• Kraft R (2015)  
  STIM and ORAI proteins in the nervous system. 
  Channels (Austin) 9:235-243.
• Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R (2015)  
  STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. 
  Glia 63:652-663.
• Kallendrusch S, Kremzow S, Nowicki M, Grabiec U, Winkelmann R, Benz A, Kraft R, Bechmann I, Dehghani F, Koch M (2013)   
  The G protein-coupled receptor 55 ligand L-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion.  
  Glia 61:1822-1831.
• Wegner F, Kraft R, Busse K, Härtig W, Leffler A, Dengler R, Schwarz J (2012)   
  Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits.   
  PLoS One 7:e36946.
• Grabiec* U, Koch* M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Straiker A, Dehghani F (2012)    
  The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB₁).   
  Neuropharmacology 62:1797-1807.
• Ödemis V, Lipfert J, Kraft R, Hajek P, Abraham G, Hattermann K, Mentlein R, Engele J (2012)    
  The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells.   
  Glia 60:372-381.
• Günther C, Laube M, Liebert UG, Kraft R (2012)    
  Differential regulation of voltage-gated Ca²⁺ currents and metabotropic glutamate receptor activity by measles virus infection in rat cortical neurons.   
  Neurosci Lett 506:17-21.
• Hoffmann* A, Grimm* C, Kraft R, Goldbaum O, Wrede A, Nolte C, Hanisch UK, Richter-Landsberg C, Brück W, Kettenmann H, Harteneck C (2010)    
  TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes.    
  J Neurochem 114:654-665.
• Wehrhahn J, Kraft R, Harteneck C, Hauschildt S (2010)     
  Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes.    
  J Immunol 184:2386-2393.
• Berna-Erro* A, Braun* A, Kraft R, Kleinschnitz C, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B (2009)      
  STIM2 regulates capacitive Ca²⁺ entry in neurons and plays a key role in hypoxic neuronal cell death.    
  Sci Signal 2:ra67.
• Wegner F, Kraft R, Busse K, Schaarschmidt G, Härtig W, Schwarz SC, Schwarz J (2009)      
  Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro.    
  J Neurochem 111:204-216.
• Schaarschmidt* G, Schewtschik* S, Kraft R, Wegner F, Eilers J, Schwarz J, Schmidt H (2009)      
  A new culturing strategy improves functional neuronal development of human neural progenitor cells.     
  J Neurochem 109:238-247.
• Wegner F, Kraft R, Busse K, Härtig W, Schaarschmidt G, Schwarz SC, Schwarz J, Hevers W (2008)      
  Functional and molecular analysis of GABA_A receptors in human midbrain-derived neural precursor cells.     
  J Neurochem 107:1056-1069.
• Kraft R (2007)      
  The Na⁺/Ca²⁺ exchange inhibitor KB-R7943 potently blocks TRPC channels.      
  Biochem Biophys Res Commun 361:230-236.
• Harteneck C, Frenzel H, Kraft R (2007)      
  N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A₂ inhibitor and TRP channel blocker.      
  Cardiovasc Drug Rev 25:69-75.
• Reiter B, Kraft R, Günzel D, Fromm M, Zeissig S, Schulzke HJ, Harteneck C (2006)      
  TRPV4-mediated regulation of epithelial permeability.       
  FASEB J 20:1802-1812.
• Kraft R, Grimm C, Frenzel H, Harteneck C (2006)      
  Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid.       
  Br J Pharmacol 148:264-273.
• Grimm* C, Kraft* R, Schultz G, Harteneck C (2005)      
  Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine.       
  Mol Pharmacol 67:798-805.
• Kraft R, Harteneck C (2005)      
  The mammalian melastatin-related transient receptor potential cation channels: an overview.       
  Pflügers Arch 451:204-211.
• Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C (2004)      
  Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.        
  Am J Physiol Cell Physiol 286:C129-C137.
• Patt S, Preussat K, Beetz C, Kraft R, Schrey M, Kalff R, Schönherr K, Heinemann SH (2004)      
  Expression of ether á go-go potassium channels in human gliomas.        
  Neurosci Lett 368:249-253.
• Grimm* C, Kraft* R, Sauerbruch S, Schultz G, Harteneck C (2003)      
  Molecular and functional characterization of the melastatin-related cation channel TRPM3.        
  J Biol Chem 278:21493-21501.
• Preussat K, Beetz C, Schrey M, Kraft R, Wölfl S, Kalff R, Patt S (2003)      
  Expression of Kv1.3 and Kv1.5 potassium channels in human gliomas.        
  Neurosci Lett 346:33-36.
• Kraft R, Krause P, Jung S, Basrai D, Liebmann L, Bolz J, Patt S (2003)      
  BK channel openers inhibit migration of human glioma cells.        
  Pflügers Arch 446:248-255.
• Schrey M, Codina C, Kraft R, Beetz C, Kalff R, Wölfl S, Patt S (2002)      
  Molecular characterization of voltage-gated sodium channels in human gliomas.        
  Neuroreport 13:2493-2498.
• Basrai D, Kraft R, Bollensdorff C, Liebmann L, Benndorf K, Patt S (2002)      
  BK channel blockers inhibit potassium-induced proliferation of human astrocytoma cells.        
  Neuroreport 13:403-407.
• Kraft R, Basrai D, Benndorf K, Patt S (2001)      
  Serum deprivation and NGF induce and modulate voltage-gated Na⁺ currents in human astrocytoma cell lines.         
  Glia 34:59-67.
• Kraft R, Benndorf K, Patt S (2000)      
  Large conductance Ca²⁺-activated K⁺ channels in human meningioma cells.          
  J Membr Biol 175:25-33.
• Patt S, Steenbeck J, Hochstetter A, Kraft R, Huonker R, Haueisen R, Haberland N, Ebmeier K, Hliscs R, Fiehler J, Nowak H, Kalff R (2000)      
  Source localization and possible causes of interictal epileptic activity in tumor-associated epilepsy.          
  Neurobiol Dis 7:260-269.
• Codina* C, Kraft* R, Pietsch T, Prinz M, Steinhäuser C, Cervós-NavarroJ, Patt S (2000)      
  Voltage- and g-aminobutyric acid-activated membrane currents in the human medulloblastoma cell line MHH-MED-3.          
  Neurosci Lett 287:53-56.
• Kaufmann R, Patt S, Zieger M, Kraft R, Tausch S, Henklein P, Nowak G (2000)      
  The two-receptor system PAR-1/PAR-4 mediates a-thrombin-induced [Ca²⁺]_i mobilization in human astrocytoma cells.          
  J Cancer Res Clin Oncol 126:91-94.
• Kaufmann R, Patt S, Zieger M, Kraft R, Nowak G (1999)      
  Presence of the proteinase-activated receptor-2 (PAR-2) in human brain tumor cells - trypsin- and SLIGRL-induced calcium response in primary cultured meningiomas.           
  Cancer Lett 139:109-113.
• Kaufmann R, Patt S, Kraft R, Zieger M, Henklein P, Neupert G, Nowak G (1999)       
  PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells.           
  J Neurooncol 42:131-136.