DFG founded research groups » Research Group Simon » Publications

Research Group Simon

Publications:

  • Simon CM, Dai Y, Van Alstyne M, Koutsioumpa C, Pagiazitis JG, Chalif JI, Wang X, Rabinowitz JE, Pellizzoni L, Henderson CE, Mentis GZ (2017)
    Converging mechanisms of p53 activation drive motor neuron degeneration in spinal muscular atrophy.
    Cell Reports 21, 3767–3780
  • Fletcher EV, Simon, CM, Pagiazitis, JG, Chalif, JI, Vukojicic, A, Drobac, E, Wang, X, and Mentis, GZ (2017)
    Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
    Nature neuroscience 20, 905-916
  • Simon CM, Janas A.M, Lotti F, Tabia JC, Pellizzoni L, Mentis GZ (2016)
    A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency
    Cell Reports 16, 1416–1430
  • Jesse CM, Bushuven E, Tripathi P, Chandrasekar A, Simon CM, Drepper C, Yamoah A, Dreser A, Katona I, Johann S, Beyer C, Wagner S, Grond M, Nikolin S, Anink J, Troost D, Sendtner M, Goswami A, Weis J (2016)
    ALS-associated endoplasmic reticulum proteins in denervated skeletal muscle: Implications for motor neuron disease pathology.
    Brain Pathology doi: 10.1111/bpa.12453
  • Mendelsohn AI, Simon CM, Abbott LF, Mentis GZ, Jessell T (2015
    Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.
    Neuron Jul 1;87(1):111-23
  • Simon CM, Gunnersen JM, Rauskolb S, Holtmann B, Drepper C, Braga M, Wiese S, Jablonka S, Puehringer D, Dombert B, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka K, Sendtner M (2015)
    Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
    Acta Neuropathol. 10.1007/s00401-015-1446-8
  • de Nooij JC, Simon CM, Simon A, Doobar S, Steel KP, Banks RW, Mentis GZ, Bewick GS, Jessell T (2015)
    The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.
    J Neurosci. 35(7):3073-84
  • Dombert B, Sivadasan R, Simon CM, Jablonka S, Sendtner M (2014)
    Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons.
    PLoS One, 10; 9(10):e110846
  • Simon CM, Jablonka, S, Ruiz, R, Tabares, L, Sendtner, M (2010)
    Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of spinal muscular atrophy.
    Hum. Mol. Genet., 19 973-986
  • Fischer, M, Pereira, PM, Holtmann, B, Simon, CM, Hanauer, A, Heisenberg, M, Sendtner, M (2009)
    P90 ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
    Mol. Cell Neurosci., 42 134-141